hegarsIn pregnancy, Hegar’s sign can be noted during a “bimanual” exam done by your doctor early in the first trimester. This is a normal symptom during pregnancy, but not a most definite sign. Hegar’s sign is the softening of the lower portion of the uterus (the cervical isthmus, which is located between the uterus and the vaginal part of the cervix) and is a pregnancy symptom that may occur as early as 4- 6 weeks along.